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KMID : 0525720100150040233
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Journal of Chitin and Chitosan
2010 Volume.15 No. 4 p.233 ~ p.236
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Effect of Low Molecular Weight Chitosan Oligosaccharide on Colon Cancer Carcinogenesis
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Lee Sang-Gil
Shin Jin-Sun
Cho Cheong-Weon
Shon Yun-Hee
Nam Kyung-Soo
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Abstract
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The effect of low molecular weight chitosan oligosaccharide (Mw<1,000) on colon cancer carcinogenesis was investigated by measuring quinone reductase (QR), glutathione S-transferase (GST) and 12-O-tetradecanoylphorbol-13-acetate(TPA)-induced ornithine decarboxylase (ODC) activities and glutathione (GSH) levels. Chitosan oligosaccharide induced QR activity in a dosedependent manner in a concentration range of 0.1~5.0 mg/mL. In addition GST activity was increased with chitosan oligosaccharide in cultured human colorectal adenocarcinoma HT-29 cells. The content of GSH was increased by the treatment of chitosan oligosaccharide. Chitosan oligosaccharide inhibited ODC activity, a key enzyme of polyamine biosynthesis. These results imply that low molecular weight chitosan oligosaccharide may suppress colon cancer carcinogenesis by increasing QR and GST activities and GSH content by inhibiting ODC activity.
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KEYWORD
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chitosan oligosaccharide, colon cancer, quinone reductase, glutathione S-transferase, ornithine decarboxylase, glutathione
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